Variable effects of different dietary saturated fatty acids on human postprandial lipaemia.
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Petaling Jaya : MPOB,
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Increased postprandial lipaemia enhances atherogenic potentials in humans. The effects of variance in dietary saturated fatty acid (SFA) composition on postprandial lipaemia was examined in 20 normolipaemic volunteers who were sequentially challenged with 3 diets with different SFA content (12:0+14:0, PIS 0.19; 16:0, PIS 0.31; 18:0, PIS 0.22). AII diets provided total fat at 31 percent energy with test fat contributing 85 percent. Subjects were preconditioned on the diets for 7 days prior to the postprandial challenge with 50g of test fat in a single breakfast mea!. Blood was sampled at baseline (fasted) and 5 times postprandially (2h, 4h, 5h, 6h, 8h). Plasma cholesterol (TC), triacylglycerol (T AG), and lipoproteins were isolated by ultracentrif\\Jgation. Postprandial response was influenced by the nature of dietary saturates tested. The 18:0 diet mediated the highest T AG response, which was significantly higher than the 16:0 and 12:0+14:0 diets. Pp peaks for TAG occurred at 5h for the 18:0 diet, 4h for the 16:0 diet and 2h for 12:0+14:0 diet. In tandem with the T AG responses, VLDL-C for the 18:0 diet peaked at 6h compared to the 4h peaks for 12:0+14:0 and 16:0 diets. After 2h HDL-C was significantly increased by the 12:0+14:0 and 16:0 diets compared to the 18:0 diet. Thereafter, HDL-C remained depressed by the 18:0 diet for the rest of the Pp periods. TC response was significantly raised by the 12:0+14:0 diet compared to 16:0 and 18:0 diets for the whole postprandial periodo This study demonstrates that postprandial lipaemia and lipoproteins are affected by the type of SFA in the diet. The nature of dietary saturates influences fat digestion and absorption in humans, in turn affecting blood lipids and lipoproteins and their raje in modulating cardiovascular risk factors.
Incluye referencias bibliográficas.
Increased postprandial lipaemia enhances atherogenic potentials in humans. The effects of variance in dietary saturated fatty acid (SFA) composition on postprandial lipaemia was examined in 20 normolipaemic volunteers who were sequentially challenged with 3 diets with different SFA content (12:0+14:0, PIS 0.19; 16:0, PIS 0.31; 18:0, PIS 0.22). AII diets provided total fat at 31 percent energy with test fat contributing 85 percent. Subjects were preconditioned on the diets for 7 days prior to the postprandial challenge with 50g of test fat in a single breakfast mea!. Blood was sampled at baseline (fasted) and 5 times postprandially (2h, 4h, 5h, 6h, 8h). Plasma cholesterol (TC), triacylglycerol (T AG), and lipoproteins were isolated by ultracentrif\\Jgation. Postprandial response was influenced by the nature of dietary saturates tested. The 18:0 diet mediated the highest T AG response, which was significantly higher than the 16:0 and 12:0+14:0 diets. Pp peaks for TAG occurred at 5h for the 18:0 diet, 4h for the 16:0 diet and 2h for 12:0+14:0 diet. In tandem with the T AG responses, VLDL-C for the 18:0 diet peaked at 6h compared to the 4h peaks for 12:0+14:0 and 16:0 diets. After 2h HDL-C was significantly increased by the 12:0+14:0 and 16:0 diets compared to the 18:0 diet. Thereafter, HDL-C remained depressed by the 18:0 diet for the rest of the Pp periods. TC response was significantly raised by the 12:0+14:0 diet compared to 16:0 and 18:0 diets for the whole postprandial periodo This study demonstrates that postprandial lipaemia and lipoproteins are affected by the type of SFA in the diet. The nature of dietary saturates influences fat digestion and absorption in humans, in turn affecting blood lipids and lipoproteins and their raje in modulating cardiovascular risk factors.
Incluye referencias bibliográficas.
Increased postprandial lipaemia enhances atherogenic potentials in humans. The effects of variance in dietary saturated fatty acid (SFA) composition on postprandial lipaemia was examined in 20 normolipaemic volunteers who were sequentially challenged with 3 diets with different SFA content (12:0+14:0, PIS 0.19; 16:0, PIS 0.31; 18:0, PIS 0.22). AII diets provided total fat at 31 percent energy with test fat contributing 85 percent. Subjects were preconditioned on the diets for 7 days prior to the postprandial challenge with 50g of test fat in a single breakfast mea!. Blood was sampled at baseline (fasted) and 5 times postprandially (2h, 4h, 5h, 6h, 8h). Plasma cholesterol (TC), triacylglycerol (T AG), and lipoproteins were isolated by ultracentrif\\Jgation. Postprandial response was influenced by the nature of dietary saturates tested. The 18:0 diet mediated the highest T AG response, which was significantly higher than the 16:0 and 12:0+14:0 diets. Pp peaks for TAG occurred at 5h for the 18:0 diet, 4h for the 16:0 diet and 2h for 12:0+14:0 diet. In tandem with the T AG responses, VLDL-C for the 18:0 diet peaked at 6h compared to the 4h peaks for 12:0+14:0 and 16:0 diets. After 2h HDL-C was significantly increased by the 12:0+14:0 and 16:0 diets compared to the 18:0 diet. Thereafter, HDL-C remained depressed by the 18:0 diet for the rest of the Pp periods. TC response was significantly raised by the 12:0+14:0 diet compared to 16:0 and 18:0 diets for the whole postprandial periodo This study demonstrates that postprandial lipaemia and lipoproteins are affected by the type of SFA in the diet. The nature of dietary saturates influences fat digestion and absorption in humans, in turn affecting blood lipids and lipoproteins and their raje in modulating cardiovascular risk factors.
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Ácidos grasos., Grasa, GRASAS EN LA DIETA, Lípidos., Nutrición., Salud.