Use of stable isotopes to study bioconversion of polyenoic fatty acids in man.

dc.creator	Descomps, B.,
dc.creator	Boustani, S.
dc.creator	Fouret, G.
dc.creator	Leger, C.L.
dc.creator	Michel, F.
dc.creator	Monnier, L.
dc.description	After an overnight fast 4 normal subjects and 4 patients with type I diabetes who had never been given insulin were given dihomo-gamma-linolenic acid 2 g labelled with deuterium, [18, 19-2H4]20:3n-6. Blood was sampled at intervals for up to 72 h thereafter and DELTA5-desaturase activity was studied. It was possible to demonstrate in vivo the conversion of 20:3n-6 to 20:4n-6, as well as the slowness of the conversion, its dependency on insulin and its insufficiency in diabetics.
dc.description	After an overnight fast 4 normal subjects and 4 patients with type I diabetes who had never been given insulin were given dihomo-gamma-linolenic acid 2 g labelled with deuterium, [18, 19-2H4]20:3n-6. Blood was sampled at intervals for up to 72 h thereafter and DELTA5-desaturase activity was studied. It was possible to demonstrate in vivo the conversion of 20:3n-6 to 20:4n-6, as well as the slowness of the conversion, its dependency on insulin and its insufficiency in diabetics.
dc.identifier.url	https://catalogo.fedepalma.org/cgi-bin/koha/opac-detail.pl?biblionumber=23432
dc.language	d
dc.relation
dc.subject	isotopes
dc.subject	metabolism
dc.subject	polyenoic fatty acids
dc.subject	Isotopes
dc.subject	Isotopes
dc.subject	Metabolism
dc.subject	Metabolism
dc.title	Use of stable isotopes to study bioconversion of polyenoic fatty acids in man.
dc.type	text

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