| dc.creator | Descomps, B.,
autor.
aut | |
| dc.creator | Boustani, S.
56607 | |
| dc.creator | Fouret, G. | |
| dc.creator | Leger, C.L.
42489 | |
| dc.creator | Michel, F.
56510 | |
| dc.creator | Monnier, L.
56511 | |
| dc.description | After an overnight fast 4 normal subjects and 4 patients with type I diabetes who had never been given insulin were given dihomo-gamma-linolenic acid 2 g labelled with deuterium, [18, 19-2H4]20:3n-6. Blood was sampled at intervals for up to 72 h thereafter and DELTA5-desaturase activity was studied. It was possible to demonstrate in vivo the conversion of 20:3n-6 to 20:4n-6, as well as the slowness of the conversion, its dependency on insulin and its insufficiency in diabetics. | |
| dc.description | After an overnight fast 4 normal subjects and 4 patients with type I diabetes who had never been given insulin were given dihomo-gamma-linolenic acid 2 g labelled with deuterium, [18, 19-2H4]20:3n-6. Blood was sampled at intervals for up to 72 h thereafter and DELTA5-desaturase activity was studied. It was possible to demonstrate in vivo the conversion of 20:3n-6 to 20:4n-6, as well as the slowness of the conversion, its dependency on insulin and its insufficiency in diabetics. | |
| dc.language | d | |
| dc.relation | | |
| dc.subject | isotopes | |
| dc.subject | metabolism | |
| dc.subject | polyenoic fatty acids | |
| dc.subject | Isotopes | |
| dc.subject | Isotopes | |
| dc.subject | Metabolism | |
| dc.subject | Metabolism | |
| dc.title | Use of stable isotopes to study bioconversion of polyenoic fatty acids in man. | |
| dc.type | text | |
